Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia
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چکیده
منابع مشابه
A role for proinflammatory cytokines and fractalkine in analgesia, tolerance, and subsequent pain facilitation induced by chronic intrathecal morphine.
The present experiments examined the role of spinal proinflammatory cytokines [interleukin-1beta (IL-1)] and chemokines (fractalkine) in acute analgesia and in the development of analgesic tolerance, thermal hyperalgesia, and tactile allodynia in response to chronic intrathecal morphine. Chronic (5 d), but not acute (1 d), intrathecal morphine was associated with a rapid increase in proinflamma...
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ژورنال
عنوان ژورنال: Brain, Behavior, and Immunity
سال: 2008
ISSN: 0889-1591
DOI: 10.1016/j.bbi.2008.05.004